Topical Delivery of Rapamycin by Means of Microenvironment-Sensitive Core-Multi-Shell Nanocarriers: Assessment of Anti-Inflammatory Activity in an ex vivo Skin/T Cell Co-Culture Model

INTRODUCTION: Rapamycin (Rapa) is an immunosuppressive macrolide that inhibits the mechanistic target of rapamycin (mTOR) activity. Thanks to its anti-proliferative effects towards different cell types, including keratinocytes and T cells, Rapa shows promise in the treatment of skin diseases charact...

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Detalles Bibliográficos
Autores principales: Rancan, Fiorenza, Guo, Xiao, Rajes, Keerthana, Sidiropoulou, Polytimi, Zabihi, Fatemeh, Hoffmann, Luisa, Hadam, Sabrina, Blume-Peytavi, Ulrike, Rühl, Eckart, Haag, Rainer, Vogt, Annika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548260/
https://www.ncbi.nlm.nih.gov/pubmed/34712046
http://dx.doi.org/10.2147/IJN.S330716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548260/
https://www.ncbi.nlm.nih.gov/pubmed/34712046
http://dx.doi.org/10.2147/IJN.S330716

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