Preventing adolescent synaptic pruning in mouse prelimbic cortex via local knockdown of α4βδ GABA(A) receptors increases anxiety response in adulthood

Anxiety is increasingly reported, especially in adolescent females. The etiology is largely unknown, which limits effective treatment. Layer 5 prelimbic cortex (L5PL) increases anxiety responses but undergoes adolescent synaptic pruning, raising the question of the impact of pruning on anxiety. Here...

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Detalles Bibliográficos
Autores principales: Evrard, Matthew R., Li, Michael, Shen, Hui, Smith, Sheryl S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548505/
https://www.ncbi.nlm.nih.gov/pubmed/34702942
http://dx.doi.org/10.1038/s41598-021-99965-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548505/
https://www.ncbi.nlm.nih.gov/pubmed/34702942
http://dx.doi.org/10.1038/s41598-021-99965-8

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