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Preventing adolescent synaptic pruning in mouse prelimbic cortex via local knockdown of α4βδ GABA(A) receptors increases anxiety response in adulthood
Anxiety is increasingly reported, especially in adolescent females. The etiology is largely unknown, which limits effective treatment. Layer 5 prelimbic cortex (L5PL) increases anxiety responses but undergoes adolescent synaptic pruning, raising the question of the impact of pruning on anxiety. Here...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548505/ https://www.ncbi.nlm.nih.gov/pubmed/34702942 http://dx.doi.org/10.1038/s41598-021-99965-8 |