Cardiac-specific CGI-58 deficiency activates the ER stress pathway to promote heart failure in mice

Excess myocardial triacylglycerol accumulation (i.e., cardiac steatosis) impairs heart function, suggesting that enzymes promoting triacylglycerol metabolism exert essential regulatory effects on heart function. Comparative gene identification 58 (CGI-58) is a key enzyme that promotes the hydrolysis...

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Detalles Bibliográficos
Autores principales: Xie, Xin, Tie, Yi-Fan, Lai, Song, Zhang, Yun-Long, Li, Hui-Hua, Liu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548506/
https://www.ncbi.nlm.nih.gov/pubmed/34702801
http://dx.doi.org/10.1038/s41419-021-04282-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548506/
https://www.ncbi.nlm.nih.gov/pubmed/34702801
http://dx.doi.org/10.1038/s41419-021-04282-7

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