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E3-ligase knock down revealed differential titin degradation by autophagy and the ubiquitin proteasome system
The sarcomere protein titin is a major determinant of cardiomyocyte stiffness and ventricular distensibility. The constant mechanical stress on titin requires well-controlled protein quality control, the exact mechanisms of which have not yet been fully elucidated. Here, we analyzed E3-ligases poten...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548520/ https://www.ncbi.nlm.nih.gov/pubmed/34702928 http://dx.doi.org/10.1038/s41598-021-00618-7 |