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E3-ligase knock down revealed differential titin degradation by autophagy and the ubiquitin proteasome system

The sarcomere protein titin is a major determinant of cardiomyocyte stiffness and ventricular distensibility. The constant mechanical stress on titin requires well-controlled protein quality control, the exact mechanisms of which have not yet been fully elucidated. Here, we analyzed E3-ligases poten...

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Detalles Bibliográficos
Autores principales:	Müller, Erik, Salcan, Senem, Bongardt, Sabine, Barbosa, David Monteiro, Krüger, Martina, Kötter, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548520/ https://www.ncbi.nlm.nih.gov/pubmed/34702928 http://dx.doi.org/10.1038/s41598-021-00618-7

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