Involvement of PBRM1 in VHL disease-associated clear cell renal cell carcinoma and its putative relationship with the HIF pathway

Von Hippel-Lindau (VHL) disease is the main cause of inherited clear-cell renal cell carcinoma (ccRCC) and is caused by germline mutations in the VHL tumor suppressor gene. Bi-allelic VHL alterations lead to inactivation of pVHL, which plays a major role by downstream activation of the hypoxia induc...

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Detalles Bibliográficos
Autores principales: Gad, Sophie, Le Teuff, Gwenaël, Nguyen, Baptiste, Verkarre, Virginie, Duchatelle, Veronique, Molinie, Vincent, Posseme, Katia, Grandon, Benjamin, Da Costa, Melanie, Job, Bastien, Meurice, Guillaume, Droin, Nathalie, Mejean, Arnaud, Couve, Sophie, Renaud, Flore, Gardie, Betty, Teh, Bin Tean, Richard, Stephane, Ferlicot, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548775/
https://www.ncbi.nlm.nih.gov/pubmed/34712359
http://dx.doi.org/10.3892/ol.2021.13096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548775/
https://www.ncbi.nlm.nih.gov/pubmed/34712359
http://dx.doi.org/10.3892/ol.2021.13096

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