KDM6A mutations promote acute cytoplasmic DNA release, DNA damage response and mitosis defects

BACKGROUND: KDM6A, encoding a histone demethylase, is one of the top ten mutated epigenetic cancer genes. The effect of mutations on its structure and function are however poorly characterized. METHODS: Database search identified nonsense and missense mutations in the N-terminal TPR motifs and the C...

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Detalles Bibliográficos
Autores principales: Koch, J., Lang, A., Whongsiri, P., Schulz, W. A., Hoffmann, M. J., Greife, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549169/
https://www.ncbi.nlm.nih.gov/pubmed/34702163
http://dx.doi.org/10.1186/s12860-021-00394-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549169/
https://www.ncbi.nlm.nih.gov/pubmed/34702163
http://dx.doi.org/10.1186/s12860-021-00394-2

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