Cytoplasmic Tail Truncation of SARS-CoV-2 Spike Protein Enhances Titer of Pseudotyped Vectors but Masks the Effect of the D614G Mutation

The high pathogenicity of SARS-CoV-2 requires it to be handled under biosafety level 3 conditions. Consequently, Spike protein-pseudotyped vectors are a useful tool to study viral entry and its inhibition, with retroviral, lentiviral (LV), and vesicular stomatitis virus (VSV) vectors the most common...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Hsu-Yu, Huang, Chun, Tian, Lu, Huang, Xiaoli, Zhang, Chennan, Llewellyn, George N., Rogers, Geoffrey L., Andresen, Kevin, O’Gorman, Maurice R. G., Chen, Ya-Wen, Cannon, Paula M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Structure and Assembly
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549521/
https://www.ncbi.nlm.nih.gov/pubmed/34495700
http://dx.doi.org/10.1128/JVI.00966-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549521/
https://www.ncbi.nlm.nih.gov/pubmed/34495700
http://dx.doi.org/10.1128/JVI.00966-21

Ejemplares similares