The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2–HO-1 Axis

Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. It is highly resistant to chemotherapy, and tumor recurrence is common. Neuronal precursor cell-expressed developmentally downregulated 4-1 (NEDD4-1) is an E3 ligase that controls embryonic development and ani...

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Detalles Bibliográficos
Autores principales: Chuang, Hao-Yu, Hsu, Li-Yun, Pan, Chih-Ming, Pikatan, Narpati Wesa, Yadav, Vijesh Kumar, Fong, Iat-Hang, Chen, Chao-Hsuan, Yeh, Chi-Tai, Chiu, Shao-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549703/
https://www.ncbi.nlm.nih.gov/pubmed/34638586
http://dx.doi.org/10.3390/ijms221910247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549703/
https://www.ncbi.nlm.nih.gov/pubmed/34638586
http://dx.doi.org/10.3390/ijms221910247

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