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Molecular basis for acyl carrier protein–ketoreductase interaction in trans-acyltransferase polyketide synthases

The biosynthesis of polyketides by type I modular polyketide synthases (PKS) relies on co-ordinated interactions between acyl carrier protein (ACP) domains and catalytic domains within the megasynthase. Despite the importance of these interactions, and their implications for biosynthetic engineering...

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Detalles Bibliográficos
Autores principales: Passmore, Munro, Gallo, Angelo, Lewandowski, Józef R., Jenner, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549798/
https://www.ncbi.nlm.nih.gov/pubmed/34760152
http://dx.doi.org/10.1039/d1sc03478b