Structural insights into the role of DNA-PK as a master regulator in NHEJ

DNA-dependent protein kinase catalytic subunit DNA-PKcs/PRKDC is the largest serine/threonine protein kinase of the phosphatidyl inositol 3-kinase-like protein kinase (PIKK) family and is the most highly expressed PIKK in human cells. With its DNA-binding partner Ku70/80, DNA-PKcs is required for re...

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Detalles Bibliográficos
Autores principales: Chen, Siyu, Lees-Miller, James P., He, Yuan, Lees-Miller, Susan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549938/
https://www.ncbi.nlm.nih.gov/pubmed/34723130
http://dx.doi.org/10.1007/s42764-021-00047-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549938/
https://www.ncbi.nlm.nih.gov/pubmed/34723130
http://dx.doi.org/10.1007/s42764-021-00047-w

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