RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunoprecipitation showed that RNF43 can interact with the...

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Detalles Bibliográficos
Autores principales: Radaszkiewicz, Tomasz, Nosková, Michaela, Gömöryová, Kristína, Vondálová Blanářová, Olga, Radaszkiewicz, Katarzyna Anna, Picková, Markéta, Víchová, Ráchel, Gybeľ, Tomáš, Kaiser, Karol, Demková, Lucia, Kučerová, Lucia, Bárta, Tomáš, Potěšil, David, Zdráhal, Zbyněk, Souček, Karel, Bryja, Vítězslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550759/
https://www.ncbi.nlm.nih.gov/pubmed/34702444
http://dx.doi.org/10.7554/eLife.65759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550759/
https://www.ncbi.nlm.nih.gov/pubmed/34702444
http://dx.doi.org/10.7554/eLife.65759

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