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RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunoprecipitation showed that RNF43 can interact with the...
Autores principales: | Radaszkiewicz, Tomasz, Nosková, Michaela, Gömöryová, Kristína, Vondálová Blanářová, Olga, Radaszkiewicz, Katarzyna Anna, Picková, Markéta, Víchová, Ráchel, Gybeľ, Tomáš, Kaiser, Karol, Demková, Lucia, Kučerová, Lucia, Bárta, Tomáš, Potěšil, David, Zdráhal, Zbyněk, Souček, Karel, Bryja, Vítězslav |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550759/ https://www.ncbi.nlm.nih.gov/pubmed/34702444 http://dx.doi.org/10.7554/eLife.65759 |
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