Evolution of kinase polypharmacology across HSP90 drug discovery

Most small molecules interact with several target proteins but this polypharmacology is seldom comprehensively investigated or explicitly exploited during drug discovery. Here, we use computational and experimental methods to identify and systematically characterize the kinase cross-pharmacology of...

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Detalles Bibliográficos
Autores principales: Antolin, Albert A., Clarke, Paul A., Collins, Ian, Workman, Paul, Al-Lazikani, Bissan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550792/
https://www.ncbi.nlm.nih.gov/pubmed/34077750
http://dx.doi.org/10.1016/j.chembiol.2021.05.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550792/
https://www.ncbi.nlm.nih.gov/pubmed/34077750
http://dx.doi.org/10.1016/j.chembiol.2021.05.004

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