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Evolution of kinase polypharmacology across HSP90 drug discovery
Most small molecules interact with several target proteins but this polypharmacology is seldom comprehensively investigated or explicitly exploited during drug discovery. Here, we use computational and experimental methods to identify and systematically characterize the kinase cross-pharmacology of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550792/ https://www.ncbi.nlm.nih.gov/pubmed/34077750 http://dx.doi.org/10.1016/j.chembiol.2021.05.004 |