MLH1 promoter hypermethylation predicts poorer prognosis in mismatch repair deficiency endometrial carcinomas

OBJECTIVE: The antitumor effects of anti-PD-1 antibody against mismatch repair deficiency (MMR-D)-associated cancers have been reported. MMR-D is found in approximately 20%–30% of endometrial carcinomas (ECs) and frequently occurs due to MLH1 promoter hypermethylation (MLH1-PHM). ECs with MLH1-PHM a...

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Detalles Bibliográficos
Autores principales: Kaneko, Enami, Sato, Naoki, Sugawara, Tae, Noto, Aya, Takahashi, Kazue, Makino, Kenichi, Terada, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550932/
https://www.ncbi.nlm.nih.gov/pubmed/34431253
http://dx.doi.org/10.3802/jgo.2021.32.e79

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550932/
https://www.ncbi.nlm.nih.gov/pubmed/34431253
http://dx.doi.org/10.3802/jgo.2021.32.e79

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