Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia

Deregulation of the EVI1 proto-oncogene by the GATA2 distal hematopoietic enhancer (G2DHE) is a key event in high-risk acute myeloid leukemia carrying 3q21q26 aberrations (3q-AML). Upon chromosomal rearrangement, G2DHE acquires characteristics of a super-enhancer and causes overexpression of EVI1 at...

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Detalles Bibliográficos
Autores principales: Kiehlmeier, Sandra, Rafiee, Mahmoud-Reza, Bakr, Ali, Mika, Jagoda, Kruse, Sabrina, Müller, Judith, Schweiggert, Sabrina, Herrmann, Carl, Sigismondo, Gianluca, Schmezer, Peter, Krijgsveld, Jeroen, Gröschel, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550965/
https://www.ncbi.nlm.nih.gov/pubmed/33911178
http://dx.doi.org/10.1038/s41375-021-01235-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550965/
https://www.ncbi.nlm.nih.gov/pubmed/33911178
http://dx.doi.org/10.1038/s41375-021-01235-z

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