ATP-Competitive Partial Antagonists of IRE1α’s RNase Segregate Outputs of the UPR

The unfolded protein response (UPR) homeostatically matches endoplasmic reticulum (ER) protein-folding capacity to cellular secretory needs. But under high/chronic ER stress, the UPR triggers apoptosis. This dichotomy is promoted by differential activation of the ER transmembrane kinase/endoribonucl...

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Detalles Bibliográficos
Autores principales: Feldman, Hannah C., Ghosh, Rajarshi, Auyeung, Vincent C., Mueller, James L., Kim, Jae-Hong, Potter, Zachary E., Vidadala, Venkata N., Perera, B. Gayani K., Olivier, Alina, Backes, Bradley J., Zikherman, Julie, Papa, Feroz R., Maly, Dustin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551014/
https://www.ncbi.nlm.nih.gov/pubmed/34556859
http://dx.doi.org/10.1038/s41589-021-00852-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551014/
https://www.ncbi.nlm.nih.gov/pubmed/34556859
http://dx.doi.org/10.1038/s41589-021-00852-0

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