Microglial transcription profiles in mouse and human are driven by APOE4 and sex

Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 is known to affect the function of microglia, but to what extent this gene drives microglial gene expression has thus far not been examined. Using a transgenic mouse model of AD that expresses...

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Detalles Bibliográficos
Autores principales: Moser, V. Alexandra, Workman, Michael J., Hurwitz, Samantha J., Lipman, Rachel M., Pike, Christian J., Svendsen, Clive N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551075/
https://www.ncbi.nlm.nih.gov/pubmed/34746703
http://dx.doi.org/10.1016/j.isci.2021.103238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551075/
https://www.ncbi.nlm.nih.gov/pubmed/34746703
http://dx.doi.org/10.1016/j.isci.2021.103238

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