Cargando…

Microglial transcription profiles in mouse and human are driven by APOE4 and sex

Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 is known to affect the function of microglia, but to what extent this gene drives microglial gene expression has thus far not been examined. Using a transgenic mouse model of AD that expresses...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moser, V. Alexandra, Workman, Michael J., Hurwitz, Samantha J., Lipman, Rachel M., Pike, Christian J., Svendsen, Clive N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551075/ https://www.ncbi.nlm.nih.gov/pubmed/34746703 http://dx.doi.org/10.1016/j.isci.2021.103238

Ejemplares similares

APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice
por: Stephen, T. L., et al.
Publicado: (2019)

Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice
por: Moser, V. Alexandra, et al.
Publicado: (2017)

Recent advances in human iPSC-derived models of the blood–brain barrier
por: Workman, Michael J., et al.
Publicado: (2020)

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau
por: Kang, Silvia S., et al.
Publicado: (2018)

APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice
por: Stephen, T. L., et al.
Publicado: (2022)

ApoE facilitates the microglial response to amyloid plaque pathology
por: Ulrich, Jason D., et al.
Publicado: (2018)

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
por: Wang, Na, et al.
Publicado: (2022)

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
por: Lee, Sangderk, et al.
Publicado: (2023)

The role of ApoE-mediated microglial lipid metabolism in brain aging and disease
por: Yen, Jui-Hung Jimmy, et al.
Publicado: (2023)

Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife
por: Zokaei, Nahid, et al.
Publicado: (2017)

Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations
por: Patel, Tulsi, et al.
Publicado: (2022)

Tissue clearing of human iPSC-derived organ-chips enables high resolution imaging and analysis
por: Ondatje, Briana N., et al.
Publicado: (2022)

Effects of APOE Genotype and Western Diet on Metabolic Phenotypes in Female Mice
por: Christensen, Amy, et al.
Publicado: (2023)

APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles
por: Ferrari-Souza, João Pedro, et al.
Publicado: (2023)

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
por: Wong, Man Ying, et al.
Publicado: (2020)

Environmentally enriched pigs have transcriptional profiles consistent with neuroprotective effects and reduced microglial activity
por: Brown, S.M., et al.
Publicado: (2018)

The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology
por: Lau, Shun-Fat, et al.
Publicado: (2023)

Sex Differences in Presynaptic Density and Neurogenesis in Middle-Aged ApoE4 and ApoE Knockout Mice
por: Rijpma, A., et al.
Publicado: (2013)

Investigation of Sex Differences in the Microglial Response to Binge Ethanol and Exercise
por: Barton, Emily A., et al.
Publicado: (2017)

Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease
por: Kang, Seokjo, et al.
Publicado: (2020)

Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids
por: Workman, Michael J., et al.
Publicado: (2020)

The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
por: Nelson, Maxine R., et al.
Publicado: (2023)

Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation
por: DePaula-Silva, Ana Beatriz, et al.
Publicado: (2019)

Microglial amyloid beta clearance is driven by PIEZO1 channels
por: Jäntti, Henna, et al.
Publicado: (2022)

Uncovering microglial pathways driving sex-specific neurobiological effects in stress and depression
por: Bollinger, J.L.
Publicado: (2021)

Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice
por: Shang, Yuan, et al.
Publicado: (2020)

Transcriptional and epigenetic decoding of the microglial aging process
por: Li, Xiaoyu, et al.
Publicado: (2023)

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
por: Arnold, Matthias, et al.
Publicado: (2020)

Three-Dimensional Analysis of Sex- and Gonadal Status- Dependent Microglial Activation in a Mouse Model of Parkinson’s Disease
por: Isenbrandt, Amandine, et al.
Publicado: (2023)

Novel Influences of Sex and APOE Genotype on Spinal Plasticity and Recovery of Function after Spinal Cord Injury
por: Strattan, Lydia E., et al.
Publicado: (2021)

Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions
por: Haghani, Amin, et al.
Publicado: (2020)

Automatic Counting of Microglial Cells in Healthy and Glaucomatous Mouse Retinas
por: de Gracia, Pablo, et al.
Publicado: (2015)

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology
por: Smith, Amy M., et al.
Publicado: (2021)

Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer’s disease
por: Hua, Jennifer, et al.
Publicado: (2023)

Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy
por: Beccari, Sol, et al.
Publicado: (2023)

Mapping of Microglial Brain Region, Sex and Age Heterogeneity in Obesity
por: Milanova, Irina V., et al.
Publicado: (2021)

APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls
por: Sampedro, Frederic, et al.
Publicado: (2015)

Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice
por: Ritzel, Rodney M., et al.
Publicado: (2022)

Experimental colitis reduces microglial cell activation in the mouse brain without affecting microglial cell numbers
por: Sroor, Hoda M., et al.
Publicado: (2019)

An Apo-14 Promoter-Driven Transgenic Zebrafish That Marks Liver Organogenesis
por: Wang, Rui, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_fulhgpgg692tfeup464kpemd48