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Acetyl-CoA derived from hepatic mitochondrial fatty acid β-oxidation aggravates inflammation by enhancing p65 acetylation

Acetylation coordinates many biological processes to ensure cells respond appropriately to nutrients. However, how acetylation regulates lipid surplus-induced inflammation remains poorly understood. Here, we found that a high-fat diet (HFD) enhanced mitochondrial fatty acid β-oxidation, which enhanc...

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Detalles Bibliográficos
Autores principales: Chen, Qiang, Du, Jianlong, Cui, Kun, Fang, Wei, Zhao, Zengqi, Chen, Qiuchi, Mai, Kangsen, Ai, Qinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551082/
https://www.ncbi.nlm.nih.gov/pubmed/34746707
http://dx.doi.org/10.1016/j.isci.2021.103244