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Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer
Immunocompetent pet dogs develop spontaneous, human-like cancers, representing a parallel patient population for the investigation of chimeric antigen receptor (CAR) therapies. We have optimized a retrovirus-based protocol to efficiently CAR transduce primary T cells from healthy and tumor-bearing d...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551231/ https://www.ncbi.nlm.nih.gov/pubmed/34746864 http://dx.doi.org/10.1016/j.xpro.2021.100905 |