Negative inotropic mechanisms of β-cardiotoxin in cardiomyocytes by depression of myofilament ATPase activity without activation of the classical β-adrenergic pathway

Beta-cardiotoxin (β-CTX) from the king cobra venom (Ophiophagus hannah) was previously proposed as a novel β-adrenergic blocker. However, the involvement of β-adrenergic signaling by this compound has never been elucidated. The objectives of this study were to investigate the underlying mechanisms o...

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Detalles Bibliográficos
Autores principales: Lertwanakarn, Tuchakorn, Suntravat, Montamas, Sánchez, Elda E., Wolska, Beata M., Solaro, R. John, de Tombe, Pieter P., Tachampa, Kittipong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551325/
https://www.ncbi.nlm.nih.gov/pubmed/34707114
http://dx.doi.org/10.1038/s41598-021-00282-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551325/
https://www.ncbi.nlm.nih.gov/pubmed/34707114
http://dx.doi.org/10.1038/s41598-021-00282-x

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