Cargando…

Negative inotropic mechanisms of β-cardiotoxin in cardiomyocytes by depression of myofilament ATPase activity without activation of the classical β-adrenergic pathway

Beta-cardiotoxin (β-CTX) from the king cobra venom (Ophiophagus hannah) was previously proposed as a novel β-adrenergic blocker. However, the involvement of β-adrenergic signaling by this compound has never been elucidated. The objectives of this study were to investigate the underlying mechanisms o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lertwanakarn, Tuchakorn, Suntravat, Montamas, Sánchez, Elda E., Wolska, Beata M., Solaro, R. John, de Tombe, Pieter P., Tachampa, Kittipong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551325/ https://www.ncbi.nlm.nih.gov/pubmed/34707114 http://dx.doi.org/10.1038/s41598-021-00282-x

Ejemplares similares

Suppression of cardiomyocyte functions by β-CTX isolated from the Thai king cobra (Ophiophagus hannah) venom via an alternative method
por: Lertwanakarn, Tuchakorn, et al.
Publicado: (2020)

Novel Approach to Assess Cardiac Function Using Systolic Performance and Myocardial Performance Indices From Simultaneous Electrocardiography and Phonocardiography Recordings in Dogs With Various Stages of Myxomatous Mitral Valve Disease
por: Gicana, Karlo Romano B., et al.
Publicado: (2021)

The Positive Inotropic Effect of Pyruvate Involves an Increase in Myofilament Calcium Sensitivity
por: Torres, Carlos A. A., et al.
Publicado: (2013)

Is there a gender-dependent negative inotropic effect of Methylene blue on the contractile performance on the level of myofilaments?
por: Bening, Constanze, et al.
Publicado: (2015)

Accessibility of Myofilament Cysteines and Effects on ATPase Depend on the Activation State during Exposure to Oxidants
por: Gross, Sean M., et al.
Publicado: (2013)

Antiviral Activity of Ribavirin against Tilapia tilapinevirus in Fish Cells
por: Lertwanakarn, Tuchakorn, et al.
Publicado: (2021)

Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts
por: Rhodes, Samhita S, et al.
Publicado: (2006)

Impact of anesthesia and storage on posttranslational modifications of cardiac myofilament proteins
por: Utter, Megan S, et al.
Publicado: (2015)

Depressed β‐adrenergic inotropic responsiveness and intracellular calcium handling abnormalities in Duchenne Muscular Dystrophy patients’ induced pluripotent stem cell–derived cardiomyocytes
por: Mekies, Lucy N., et al.
Publicado: (2021)

The Modulation of Immune Responses in Tilapinevirus tilapiae-Infected Fish Cells through MAPK/ERK Signalling
por: Lertwanakarn, Tuchakorn, et al.
Publicado: (2023)

Recombinant disintegrin (r-Cam-dis) from Crotalus adamanteus inhibits adhesion of human pancreatic cancer cell lines to laminin-1 and vitronectin
por: Suntravat, Montamas, et al.
Publicado: (2015)

Proteomic Profiling of Extracellular Vesicles Isolated from Plasma and Peritoneal Exudate in Mice Induced by Crotalus scutulatus scutulatus Crude Venom and Its Purified Cysteine-Rich Secretory Protein (Css-CRiSP)
por: Reyes, Armando, et al.
Publicado: (2023)

Cathepsin K activity controls cardiotoxin‐induced skeletal muscle repair in mice
por: Ogasawara, Shinyu, et al.
Publicado: (2017)

Unique patterns of cardiogenic and fibrotic gene expression in rat cardiac fibroblasts
por: Tachampa, Kittipong, et al.
Publicado: (2020)

Novel control of cardiac myofilament response to calcium by S-glutathionylation at specific sites of myosin binding protein C
por: Patel, Bindiya G., et al.
Publicado: (2013)

Subcellular Propagation of Cardiomyocyte β-Adrenergic Activation of Calcium Uptake Involves Internal β-Receptors and AKAP7
por: Shannon, Thomas R, et al.
Publicado: (2022)

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I
por: Siddiqui, Jalal K., et al.
Publicado: (2016)

Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response
por: Chowdhury, Shamim A. K., et al.
Publicado: (2020)

Gene expression profiling of the venomgland from the Venezuelan mapanare (Bothrops colombiensis) using expressed sequence tags (ESTs)
por: Suntravat, Montamas, et al.
Publicado: (2016)

Erratum to: Gene expression profiling of the venom gland from the Venezuelan mapanare (Bothrops colombiensis) using expressed sequence tags (ESTs)
por: Suntravat, Montamas, et al.
Publicado: (2016)

Tilapia lake virus causes mitochondrial damage: a proposed mechanism that leads to extensive death in fish cells
por: Raksaseri, Promporn, et al.
Publicado: (2023)

Evaluation of Signaling Pathways Profiling in Human Dermal Endothelial Cells Treated by Snake Venom Cysteine-Rich Secretory Proteins (svCRiSPs) from North American Snakes Using Reverse Phase Protein Array (RPPA)
por: Suntravat, Montamas, et al.
Publicado: (2021)

Effects of Cardiotoxins on Cardiac Stem and Progenitor Cell Populations
por: Smith, Andrew J.
Publicado: (2021)

Effects of Cobra Cardiotoxins on Intracellular Calcium and the Contracture of Rat Cardiomyocytes Depend on Their Structural Types
por: Averin, Alexey S., et al.
Publicado: (2023)

Purification of a phospholipase A(2) from Daboia russelii siamensis venom with anticancer effects
por: Khunsap, Suchitra, et al.
Publicado: (2011)

Vasopressor stays vasopressor and inotrope stays inotrope!
por: Luckner, Günter, et al.
Publicado: (2008)

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes
por: Bathe-Peters, Marc, et al.
Publicado: (2021)

The Myofilament Lattice: Studies on Isolated Fibers : III. The effect of myofilament spacing upon tension
por: April, Ernest W., et al.
Publicado: (1973)

Sarco/endoplasmic reticulum calcium ATPase activity is unchanged despite increased myofilament calcium sensitivity in Zucker type 2 diabetic fatty rat heart
por: Ng, Yann Huey, et al.
Publicado: (2022)

Beta-synemin expression in cardiotoxin-injected rat skeletal muscle
por: Mizuno, Yuji, et al.
Publicado: (2007)

Metformin Protects Skeletal Muscle from Cardiotoxin Induced Degeneration
por: Langone, Francesca, et al.
Publicado: (2014)

Skeletal Muscle Regeneration in Cardiotoxin-Induced Muscle Injury Models
por: Wang, Yanjie, et al.
Publicado: (2022)

Induction of Skeletal Muscle Injury by Intramuscular Injection of Cardiotoxin in Mouse
por: Fu, Xin, et al.
Publicado: (2023)

Activation of β(2) adrenergic receptors promotes adult hippocampal neurogenesis
por: Bortolotto, Valeria, et al.
Publicado: (2020)

Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes
por: Briston, Sarah J., et al.
Publicado: (2014)

Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity
por: Sala, Andrea, et al.
Publicado: (2018)

Carvedilol Prevents Redox Inactivation of Cardiomyocyte Β(1)-Adrenergic Receptors
por: Park, Misun, et al.
Publicado: (2018)

β‐Adrenergic signaling in skin cancer
por: Batalla‐Covello, Jennifer, et al.
Publicado: (2022)

Vasopressin Is No Inotrope
por: Roeleveld, Peter Paul
Publicado: (2018)

Total inotrope exposure score: an extension of the vasoactive inotrope score
por: Bangalore, H, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_lfql728l8ja533dneu7v3rdqge