Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission

Inhibitory GABA-ergic neurotransmission is fundamental for the adult vertebrate central nervous system and requires low chloride concentration in neurons, maintained by KCC2, a neuroprotective ion transporter that extrudes intracellular neuronal chloride. To identify Kcc2 gene expression‑enhancing c...

Descripción completa

Detalles Bibliográficos
Autores principales: Yeo, Michele, Chen, Yong, Jiang, Changyu, Chen, Gang, Wang, Kaiyuan, Chandra, Sharat, Bortsov, Andrey, Lioudyno, Maria, Zeng, Qian, Wang, Peng, Wang, Zilong, Busciglio, Jorge, Ji, Ru-Rong, Liedtke, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551327/
https://www.ncbi.nlm.nih.gov/pubmed/34707084
http://dx.doi.org/10.1038/s41467-021-26270-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551327/
https://www.ncbi.nlm.nih.gov/pubmed/34707084
http://dx.doi.org/10.1038/s41467-021-26270-3

Ejemplares similares