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Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission
Inhibitory GABA-ergic neurotransmission is fundamental for the adult vertebrate central nervous system and requires low chloride concentration in neurons, maintained by KCC2, a neuroprotective ion transporter that extrudes intracellular neuronal chloride. To identify Kcc2 gene expression‑enhancing c...
Autores principales: | Yeo, Michele, Chen, Yong, Jiang, Changyu, Chen, Gang, Wang, Kaiyuan, Chandra, Sharat, Bortsov, Andrey, Lioudyno, Maria, Zeng, Qian, Wang, Peng, Wang, Zilong, Busciglio, Jorge, Ji, Ru-Rong, Liedtke, Wolfgang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551327/ https://www.ncbi.nlm.nih.gov/pubmed/34707084 http://dx.doi.org/10.1038/s41467-021-26270-3 |
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