Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR

Programmed cell death ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) cascade is an effective therapeutic target for immune checkpoint blockade (ICB) therapy. Targeting PD-L1/PD-1 axis by small-molecule drug is an attractive approach to enhance antitumor immunity. Using flow cytometry-based...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xiaojia, Yin, Mingxiao, Dong, Jingwen, Mao, Genxiang, Min, Wenjian, Kuang, Zean, Yang, Peng, Liu, Lu, Zhang, Na, Deng, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551420/
https://www.ncbi.nlm.nih.gov/pubmed/34745852
http://dx.doi.org/10.1016/j.apsb.2021.03.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551420/
https://www.ncbi.nlm.nih.gov/pubmed/34745852
http://dx.doi.org/10.1016/j.apsb.2021.03.039

Ejemplares similares