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Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR

Programmed cell death ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) cascade is an effective therapeutic target for immune checkpoint blockade (ICB) therapy. Targeting PD-L1/PD-1 axis by small-molecule drug is an attractive approach to enhance antitumor immunity. Using flow cytometry-based...

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Detalles Bibliográficos
Autores principales:	Liu, Xiaojia, Yin, Mingxiao, Dong, Jingwen, Mao, Genxiang, Min, Wenjian, Kuang, Zean, Yang, Peng, Liu, Lu, Zhang, Na, Deng, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551420/ https://www.ncbi.nlm.nih.gov/pubmed/34745852 http://dx.doi.org/10.1016/j.apsb.2021.03.039

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