The correlation between the level of 3-hydroxypropyl mercapturic acid, CYP2B6 polymorphisms, and hematuria occurrences after cyclophosphamide administration and its bioanalytical methods: A systematic review

BACKGROUND: Cyclophosphamide (CPA) is a cytotoxic prodrug that needs to be metabolized by cytochrome P450 enzymes, like CYP2B6. Unfortunately, CYP2B6 is a very polymorphic enzyme and can cause a change in 3-hydroxypropyl mercapturic acid (3-HPMA), the most found CYP metabolite in urine levels. Chang...

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Detalles Bibliográficos
Autores principales: Harahap, Yahdiana, Nurahman, Farhan, Purwanto, Denni Joko, Yanuar, Arry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551512/
https://www.ncbi.nlm.nih.gov/pubmed/34746455
http://dx.doi.org/10.1016/j.heliyon.2021.e08126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551512/
https://www.ncbi.nlm.nih.gov/pubmed/34746455
http://dx.doi.org/10.1016/j.heliyon.2021.e08126

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