G-749 Promotes Receptor Tyrosine Kinase TYRO3 Degradation and Induces Apoptosis in Both Colon Cancer Cell Lines and Xenograft Mouse Models

G-749 is an FLT3 kinase inhibitor that was originally developed as a treatment for acute myeloid leukemia. Some FLT3 kinase inhibitors are dual kinase inhibitors that inhibit the TAM (Tyro3, Axl, Mer) receptor tyrosine kinase family and are used to treat solid cancers such as non-small cell lung can...

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Detalles Bibliográficos
Autores principales: Kim, Hae Dong, Park, Eun Jung, Choi, Eun Kyoung, Song, Seuk Young, Hoe, Kwang-Lae, Kim, Dong-Uk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551583/
https://www.ncbi.nlm.nih.gov/pubmed/34721022
http://dx.doi.org/10.3389/fphar.2021.730241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551583/
https://www.ncbi.nlm.nih.gov/pubmed/34721022
http://dx.doi.org/10.3389/fphar.2021.730241

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