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The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer
In 2003, the sequences of mammalian proprotein convertase subtilisin/kexin type 9 (PCSK9) were reported. Radiolabeling pulse-chase analyses demonstrated that PCSK9 was synthesized as a precursor (proPCSK9) that undergoes autocatalytic cleavage in the endoplasmic reticulum into PCSK9, which is then s...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551645/ https://www.ncbi.nlm.nih.gov/pubmed/34606887 http://dx.doi.org/10.1016/j.jlr.2021.100130 |