Replication stress inhibits synthesis of histone mRNAs in yeast by removing Spt10p and Spt21p from the histone promoters

Proliferating cells coordinate histone and DNA synthesis to maintain correct stoichiometry for chromatin assembly. Histone mRNA levels must be repressed when DNA replication is inhibited to prevent toxicity and genome instability due to free non-chromatinized histone proteins. In mammalian cells, re...

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Detalles Bibliográficos
Autores principales: Bhagwat, Madhura, Nagar, Shreya, Kaur, Pritpal, Mehta, Riddhi, Vancurova, Ivana, Vancura, Ales
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551654/
https://www.ncbi.nlm.nih.gov/pubmed/34582893
http://dx.doi.org/10.1016/j.jbc.2021.101246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551654/
https://www.ncbi.nlm.nih.gov/pubmed/34582893
http://dx.doi.org/10.1016/j.jbc.2021.101246

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