Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma

The protein Lgl1 is a key regulator of cell polarity. We previously showed that Lgl1 is inactivated by hyperphosphorylation in glioblastoma as a consequence of PTEN tumour suppressor loss and aberrant activation of the PI 3-kinase pathway; this contributes to glioblastoma pathogenesis both by promot...

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Detalles Bibliográficos
Autores principales: Lavictoire, Sylvie J., Jomaa, Danny, Gont, Alexander, Jardine, Karen, Cook, David P., Lorimer, Ian A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551657/
https://www.ncbi.nlm.nih.gov/pubmed/34624316
http://dx.doi.org/10.1016/j.jbc.2021.101172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551657/
https://www.ncbi.nlm.nih.gov/pubmed/34624316
http://dx.doi.org/10.1016/j.jbc.2021.101172

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