Possible Interactions of Extracellular Loop IVP2-S6 With Voltage-Sensing Domain III in Cardiac Sodium Channel

Motion transmission from voltage sensors to inactivation gates is an important problem in the general physiology of ion channels. In a cryo-EM structure of channel hNa(v)1.5, residues N1736 and R1739 in the extracellular loop IVP2-S6 approach glutamates E1225 and E1295, respectively, in the voltage-...

Descripción completa

Detalles Bibliográficos
Autores principales: Zaytseva, Anastasia K., Boitsov, Aleksandr S., Kostareva, Anna A., Zhorov, Boris S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551724/
https://www.ncbi.nlm.nih.gov/pubmed/34721031
http://dx.doi.org/10.3389/fphar.2021.742508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551724/
https://www.ncbi.nlm.nih.gov/pubmed/34721031
http://dx.doi.org/10.3389/fphar.2021.742508

Ejemplares similares