Cargando…

Anti-inflammation and antimalarial profile of 5-pyridin-2-yl-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester as a low molecular intermediate for hybrid drug synthesis

A novel 1,2,4-triazole intermediate 5-pyridin-2-yl-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester was prepared by the reaction of N’-aminopiridyne-2-carboximidamine and an excess monoethyl oxalyl chloride and screened for biological activities. The compound was structurally characterized by nuclea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eya’ane Meva, Francois, Prior, Timothy J., Evans, David J., Shah, Sachin, Tamngwa, Cynthia Fake, Belengue, Herschelle Guyenne Lagrange, Mang, Roland Emmanuel, Munro, Justin, Qahash, Tarrick, Llinás, Manuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551956/ http://dx.doi.org/10.1007/s11164-021-04607-3

Ejemplares similares

Crystal structures of N′-aminopyridine-2-carboximidamide and N′-{[1-(pyridin-2-yl)ethylidene]amino}pyridine-2-carboximidamide
por: Eya’ane Meva, Francois, et al.
Publicado: (2017)

Crystal structure of an unknown solvate of bis(tetra-n-butylammonium) [N,N′-(4-trifluoromethyl-1,2-phenylene)bis(oxamato)-κ(4) O,N,N′,O′]nickelate(II)
por: Eya’ane Meva, François, et al.
Publicado: (2015)

1,4-Dihydrobenzo[g]quinoxaline-2,3-dione
por: Eya’ane Meva, François, et al.
Publicado: (2012)

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages
por: Okombo, John, et al.
Publicado: (2022)

Chemical composition and repellent activity of essential oils of Tithonia diversifolia (Asteraceae) leaves against the bites of Anopheles coluzzii
por: Akeumbiwo Tchumkam, Cédric, et al.
Publicado: (2023)

Eco-friendly synthesis, characterization, in vitro and in vivo anti-inflammatory activity of silver nanoparticle-mediated Selaginella myosurus aqueous extract
por: Kedi, Philippe Belle Ebanda, et al.
Publicado: (2018)

A systematic review on anti-malarial drug discovery and antiplasmodial potential of green synthesis mediated metal nanoparticles: overview, challenges and future perspectives
por: Kojom Foko, Loick P., et al.
Publicado: (2019)

Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
por: Boechat, Nubia, et al.
Publicado: (2011)

5-Amino-3-(4H-1,2,4-triazol-4-yl)-1H-1,2,4-triazole
por: Liu, Bing, et al.
Publicado: (2012)

An insight on medicinal attributes of 1,2,4-triazoles
por: Aggarwal, Ranjana, et al.
Publicado: (2020)

1,2,4-Triazoles as Important Antibacterial Agents
por: Strzelecka, Małgorzata, et al.
Publicado: (2021)

Thermal Rearrangement of Allyl Substituted Unsymmetric 4H-1,2,4-Triazoles to the Corresponding 1H-1,2,4-triazoles.
por: Jørgensen, Kåre B., et al.
Publicado: (2001)

3-Pyridin-2-yl-1H-1,2,4-triazol-5-amine
por: Dolzhenko, Anton V., et al.
Publicado: (2008)

N-(1H-1,2,4-Triazol-5-yl)pyridine-2-carboxamide
por: Miao, Jing, et al.
Publicado: (2009)

[Hydrogen bis(1,2,4-triazole)] 1,2,4-triazolium bis(3-carboxy-4-hydroxybenzenesulfonate) 1,2,4-triazole disolvate
por: Qiu, Ming-qiang
Publicado: (2010)

1H-1,2,4-Triazole-3-carboxamide
por: Xie, Qing-Ruo
Publicado: (2008)

3-Nitro-1H-1,2,4-triazole
por: Hemamalini, Madhukar, et al.
Publicado: (2010)

4-(1,2,4-Triazol-1-yl)aniline
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

Regioselectivity of the alkylation of S-substituted 1,2,4-triazoles with dihaloalkanes
por: Boraei, Ahmed T. A., et al.
Publicado: (2016)

Novel series of 1,2,4-trioxane derivatives as antimalarial agents
por: Rudrapal, Mithun, et al.
Publicado: (2017)

Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles
por: Gautun, Odd R., et al.
Publicado: (2001)

2,6-Bis(4H-1,2,4-triazol-4-yl)pyridine dihydrate
por: Liu, Shang Yuan, et al.
Publicado: (2011)

2,6-Bis(4H-1,2,4-triazol-4-yl)pyridine dihydrate
por: Jiao, De-quan, et al.
Publicado: (2011)

5-(Pyridin-2-yl)-3,3′-bi(1H-1,2,4-triazole)
por: Xu, Zhouqing, et al.
Publicado: (2011)

2-(5-{6-[5-(Pyrazin-2-yl)-1H-1,2,4-triazol-3-yl]pyridin-2-yl}-1H-1,2,4-triazol-3-yl)pyrazine
por: Xu, Zhouqing, et al.
Publicado: (2011)

Quantification of Lipophilicity of 1,2,4-Triazoles Using Micellar Chromatography
por: Janicka, Małgorzata, et al.
Publicado: (2012)

Proton-Conducting Polymeric Membranes Based on 1,2,4-Triazole
por: Prozorova, Galina F., et al.
Publicado: (2023)

3-Phenyl-1H-1,2,4-triazol-5-amine–5-phenyl-1H-1,2,4-triazol-3-amine (1/1)
por: Dolzhenko, Anton V., et al.
Publicado: (2008)

N-(5-Amino-1H-1,2,4-triazol-3-yl)pyridine-2-carboxamide
por: Hernández-Gil, Javier, et al.
Publicado: (2013)

Electrocatalytic CO(2) Reduction by [Re(CO)(3)Cl(3-(pyridin-2-yl)-5-phenyl-1,2,4-triazole)] and [Re(CO)(3)Cl(3-(2-pyridyl)-1,2,4-triazole)]
por: Nguyen, Phuong N., et al.
Publicado: (2022)

1-{4-[(1H-1,2,4-Triazol-1-yl)methyl]benzyl}-1H-1,2,4-triazol-4-ium perchlorate
por: Hu, Zhao-Jian, et al.
Publicado: (2010)

2-(4H-1,2,4-Triazol-4-yl)pyrimidine
por: Wang, Qian, et al.
Publicado: (2011)

2-(4H-1,2,4-Triazol-4-yl)phenol
por: Zhao, Wang, et al.
Publicado: (2010)

Bis(4H-1,2,4-triazol-3-yl)disulfane
por: Liu, Dongsheng, et al.
Publicado: (2007)

Synthesis, antifungal and antibacterial activity of novel 1,2,4-triazole derivatives
por: Gupta, Deepa, et al.
Publicado: (2015)

Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids
por: Plech, Tomasz, et al.
Publicado: (2015)

Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives
por: Bektaş, Hakan, et al.
Publicado: (2010)

Halogen-containing heteroaromatic carbenes of the 1,2,4-triazole series and their transformations
por: Glinyanaya, Nataliya V., et al.
Publicado: (2021)

Two decades of the synthesis of mono- and bis-aminomercapto[1,2,4]triazoles
por: Riyadh, Sayed M., et al.
Publicado: (2020)

Antibacterial Activity of Fluorobenzoylthiosemicarbazides and Their Cyclic Analogues with 1,2,4-Triazole Scaffold
por: Kosikowska, Urszula, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v69nfcuccumf75vv96ibuqvk68