Surface expression of the immunotherapeutic target G(D2) in osteosarcoma depends on cell confluency

BACKGROUND: Chimeric antigen receptor (CAR) T‐cell therapy of pediatric sarcomas is challenged by the paucity of targetable cell surface antigens. A candidate target in osteosarcoma (OS) is the ganglioside G(D2), but heterogeneous expression of G(D2) limits its value. AIM: We aimed to identify mecha...

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Detalles Bibliográficos
Autores principales: Wiebel, Malena, Kailayangiri, Sareetha, Altvater, Bianca, Meltzer, Jutta, Grobe, Kay, Kupich, Sabine, Rossig, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551999/
https://www.ncbi.nlm.nih.gov/pubmed/33811471
http://dx.doi.org/10.1002/cnr2.1394

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