Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors

Chimeric antigen receptor (CAR) T cell therapy has shown unprecedented success in treating advanced hematological malignancies. Its effectiveness in solid tumors has been limited due to heterogeneous antigen expression, a suppressive tumor microenvironment, suboptimal trafficking to the tumor site a...

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Detalles Bibliográficos
Autores principales: Ghahri-Saremi, Navid, Akbari, Behnia, Soltantoyeh, Tahereh, Hadjati, Jamshid, Ghassemi, Saba, Mirzaei, Hamid Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552010/
https://www.ncbi.nlm.nih.gov/pubmed/34721401
http://dx.doi.org/10.3389/fimmu.2021.738456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552010/
https://www.ncbi.nlm.nih.gov/pubmed/34721401
http://dx.doi.org/10.3389/fimmu.2021.738456

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