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Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors

Chimeric antigen receptor (CAR) T cell therapy has shown unprecedented success in treating advanced hematological malignancies. Its effectiveness in solid tumors has been limited due to heterogeneous antigen expression, a suppressive tumor microenvironment, suboptimal trafficking to the tumor site a...

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Detalles Bibliográficos
Autores principales:	Ghahri-Saremi, Navid, Akbari, Behnia, Soltantoyeh, Tahereh, Hadjati, Jamshid, Ghassemi, Saba, Mirzaei, Hamid Reza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552010/ https://www.ncbi.nlm.nih.gov/pubmed/34721401 http://dx.doi.org/10.3389/fimmu.2021.738456

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