Contributions of UDP-Glucuronosyltransferases to Human Hepatic and Intestinal Metabolism of Ticagrelor and Inhibition of UGTs and Cytochrome P450 Enzymes by Ticagrelor and its Glucuronidated Metabolite

Ticagrelor is the first reversibly binding, direct-acting, oral P2Y(12) receptor inhibitor. The contribution of UDP-glucuronosyltransferases (UGTs) enzymes to the metabolism of ticagrelor to its glucuronide conjugation, ticagrelor-O-glucuronide, in human liver microsomes (HLM) and human intestinal m...

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Detalles Bibliográficos
Autores principales: Liu, Shuaibing, Hou, Lei, Li, Cai, Zhao, Yibo, Yao, Xia, Zhang, Xiaojian, Tian, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552062/
https://www.ncbi.nlm.nih.gov/pubmed/34721047
http://dx.doi.org/10.3389/fphar.2021.761814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552062/
https://www.ncbi.nlm.nih.gov/pubmed/34721047
http://dx.doi.org/10.3389/fphar.2021.761814

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