Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen

We report the first synthesis and immunological evaluation of a new glycoconjugate design based on streamlined saponin adjuvants and the Tn carbohydrate antigen. While the novel synthetic constructs induced moderate antibody responses in mice, the versatile chemical platform is amenable to further s...

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Detalles Bibliográficos
Autores principales: Fuentes, Roberto, Aguinagalde, Leire, Sacristán, Nagore, Fernández-Tejada, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552335/
https://www.ncbi.nlm.nih.gov/pubmed/34647563
http://dx.doi.org/10.1039/d1cc04459a
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author Fuentes, Roberto
Aguinagalde, Leire
Sacristán, Nagore
Fernández-Tejada, Alberto
author_facet Fuentes, Roberto
Aguinagalde, Leire
Sacristán, Nagore
Fernández-Tejada, Alberto
author_sort Fuentes, Roberto
collection PubMed
description We report the first synthesis and immunological evaluation of a new glycoconjugate design based on streamlined saponin adjuvants and the Tn carbohydrate antigen. While the novel synthetic constructs induced moderate antibody responses in mice, the versatile chemical platform is amenable to further structure–activity optimizations for the development of self-adjuvanting glycoconjugate cancer vaccines.
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spelling pubmed-85523352021-11-09 Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen Fuentes, Roberto Aguinagalde, Leire Sacristán, Nagore Fernández-Tejada, Alberto Chem Commun (Camb) Chemistry We report the first synthesis and immunological evaluation of a new glycoconjugate design based on streamlined saponin adjuvants and the Tn carbohydrate antigen. While the novel synthetic constructs induced moderate antibody responses in mice, the versatile chemical platform is amenable to further structure–activity optimizations for the development of self-adjuvanting glycoconjugate cancer vaccines. The Royal Society of Chemistry 2021-10-14 /pmc/articles/PMC8552335/ /pubmed/34647563 http://dx.doi.org/10.1039/d1cc04459a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Fuentes, Roberto
Aguinagalde, Leire
Sacristán, Nagore
Fernández-Tejada, Alberto
Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen
title Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen
title_full Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen
title_fullStr Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen
title_full_unstemmed Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen
title_short Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen
title_sort design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the tn antigen
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552335/
https://www.ncbi.nlm.nih.gov/pubmed/34647563
http://dx.doi.org/10.1039/d1cc04459a
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