Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease

While misfolding of alpha-synuclein (αSyn) is central to the pathogenesis of Parkinson’s disease (PD), fundamental questions about its structure and function at the synapse remain unanswered. We examine synaptosomes from non-transgenic and transgenic mice expressing wild-type human αSyn, the E46K fP...

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Detalles Bibliográficos
Autores principales: Fonseca-Ornelas, Luis, Viennet, Thibault, Rovere, Matteo, Jiang, Haiyang, Liu, Lei, Nuber, Silke, Ericsson, Maria, Arthanari, Haribabu, Selkoe, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552450/
https://www.ncbi.nlm.nih.gov/pubmed/34233191
http://dx.doi.org/10.1016/j.celrep.2021.109333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552450/
https://www.ncbi.nlm.nih.gov/pubmed/34233191
http://dx.doi.org/10.1016/j.celrep.2021.109333

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