Cargando…

Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease

While misfolding of alpha-synuclein (αSyn) is central to the pathogenesis of Parkinson’s disease (PD), fundamental questions about its structure and function at the synapse remain unanswered. We examine synaptosomes from non-transgenic and transgenic mice expressing wild-type human αSyn, the E46K fP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fonseca-Ornelas, Luis, Viennet, Thibault, Rovere, Matteo, Jiang, Haiyang, Liu, Lei, Nuber, Silke, Ericsson, Maria, Arthanari, Haribabu, Selkoe, Dennis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552450/ https://www.ncbi.nlm.nih.gov/pubmed/34233191 http://dx.doi.org/10.1016/j.celrep.2021.109333

Ejemplares similares

Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR
por: Tokunaga, Yuji, et al.
Publicado: (2020)

Retrieval and recycling of synaptic vesicle membrane in pinched-off nerve terminals (synaptosomes)
Publicado: (1978)

Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein
por: Betzer, Cristine, et al.
Publicado: (2015)

Protein Phosphorylation in Depolarized Synaptosomes: Dissecting Primary Effects of Calcium from Synaptic Vesicle Cycling
por: Silbern, Ivan, et al.
Publicado: (2021)

The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling
por: Chu, Nam, et al.
Publicado: (2020)

Synaptosomes: new vesicles for neuronal mitochondrial transplantation
por: Picone, Pasquale, et al.
Publicado: (2021)

ISOLATION OF COATED VESICLES, PLAIN SYNAPTIC VESICLES, AND FLOCCULENT MATERIAL FROM A CRUDE SYNAPTOSOME FRACTION OF GUINEA PIG WHOLE BRAIN
por: Kadota, Ken, et al.
Publicado: (1973)

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking
por: Román-Vendrell, Cristina, et al.
Publicado: (2021)

PH domain-mediated autoinhibition and oncogenic activation of Akt
por: Bae, Hwan, et al.
Publicado: (2022)

Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
por: Carnazza, Kathryn E., et al.
Publicado: (2022)

DNP-Enhanced MAS NMR: A Tool to Snapshot Conformational Ensembles of α-Synuclein in Different States
por: Uluca, Boran, et al.
Publicado: (2018)

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity
por: Ramalingam, Nagendran, et al.
Publicado: (2023)

Glycation of α-synuclein hampers its binding to synaptic-like vesicles and its driving effect on their fusion
por: Uceda, Ana Belén, et al.
Publicado: (2022)

Evolution of nanobodies specific for BCL11A
por: Yin, Maolu, et al.
Publicado: (2023)

Integrative structural dynamics probing of the conformational heterogeneity in synaptosomal-associated protein 25
por: Saikia, Nabanita, et al.
Publicado: (2021)

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons
por: Fonseca-Ornelas, Luis, et al.
Publicado: (2022)

Inhibition of Calpains Protects Mn-Induced Neurotransmitter release disorders in Synaptosomes from Mice: Involvement of SNARE Complex and Synaptic Vesicle Fusion
por: Wang, Can, et al.
Publicado: (2017)

Structural basis of synaptic vesicle assembly promoted by α-synuclein
por: Fusco, Giuliana, et al.
Publicado: (2016)

Topography of the synaptosomal membrane
Publicado: (1976)

Method and validation of synaptosomal preparation for isolation of synaptic membrane proteins from rat brain
por: Kamat, Pradip Kumar, et al.
Publicado: (2014)

A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice
por: Nuber, Silke, et al.
Publicado: (2020)

Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein
por: Fusco, Giuliana, et al.
Publicado: (2017)

Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
por: Sun, Jichao, et al.
Publicado: (2019)

Synuclein Regulates Synaptic Vesicle Clustering and Docking at a Vertebrate Synapse
por: Fouke, Kaitlyn E., et al.
Publicado: (2021)

Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering
por: Lai, Ying, et al.
Publicado: (2023)

Synaptic Proteins Linked to HIV-1 Infection and Immunoproteasome Induction: Proteomic Analysis of Human Synaptosomes
por: Gelman, Benjamin B., et al.
Publicado: (2009)

α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling
por: Medeiros, Audrey T., et al.
Publicado: (2017)

Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes
Publicado: (1983)

Comparative synaptosome imaging: a semi-quantitative method to obtain copy numbers for synaptic and neuronal proteins
por: Richter, Katharina N., et al.
Publicado: (2018)

DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function
por: Plotegher, N., et al.
Publicado: (2017)

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
por: Lautenschläger, Janin, et al.
Publicado: (2018)

A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles
por: Man, Wing K., et al.
Publicado: (2020)

α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
por: Brodin, Lennart, et al.
Publicado: (2022)

A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice
por: Kurz, Alexander, et al.
Publicado: (2010)

E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity
por: Rovere, Matteo, et al.
Publicado: (2019)

The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition
por: Man, Wing K., et al.
Publicado: (2021)

Hsc70 rescues the synaptic vesicle trafficking defects caused by α-synuclein dimers
por: Brady, Emily B., et al.
Publicado: (2023)

Coated-vesicle shells, particle/chain material, and tubulin in brain synaptosomes. An electron microscope and biochemical study
Publicado: (1976)

Local Deuteration Enables NMR Observation of Methyl Groups in Proteins from Eukaryotic and Cell‐Free Expression Systems
por: Dubey, Abhinav, et al.
Publicado: (2021)

The Synaptic Function of α-Synuclein
por: Burré, Jacqueline
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1rbmlkp11krs1g6oq3vt4l0bvh