Short Synthesis of Molnupiravir (EIDD-2801) via a Thionated Uridine Intermediate

[Image: see text] Molnupiravir (MK-4482, EIDD-2801) is an experimental drug that has been demonstrated to be effective for the treatment of COVID-19 in human clinical trials. Herein, we report a concise synthesis of the drug via a novel thionated derivative that relies on one-pot methodologies, thus...

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Autores principales: Dey, Raghunath, Nayak, Sourav, Das, Parthasarathi, Yadav, Somnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552467/
https://www.ncbi.nlm.nih.gov/pubmed/34723033
http://dx.doi.org/10.1021/acsomega.1c04550
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author Dey, Raghunath
Nayak, Sourav
Das, Parthasarathi
Yadav, Somnath
author_facet Dey, Raghunath
Nayak, Sourav
Das, Parthasarathi
Yadav, Somnath
author_sort Dey, Raghunath
collection PubMed
description [Image: see text] Molnupiravir (MK-4482, EIDD-2801) is an experimental drug that has been demonstrated to be effective for the treatment of COVID-19 in human clinical trials. Herein, we report a concise synthesis of the drug via a novel thionated derivative that relies on one-pot methodologies, thus decreasing the number of purification steps required. This route provides the drug in an overall 62% yield and >99% purity and uses cheap and readily available bulk chemicals, thereby providing an affordable synthesis of the drug for cheaper and wider global accessibility.
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spelling pubmed-85524672021-10-29 Short Synthesis of Molnupiravir (EIDD-2801) via a Thionated Uridine Intermediate Dey, Raghunath Nayak, Sourav Das, Parthasarathi Yadav, Somnath ACS Omega [Image: see text] Molnupiravir (MK-4482, EIDD-2801) is an experimental drug that has been demonstrated to be effective for the treatment of COVID-19 in human clinical trials. Herein, we report a concise synthesis of the drug via a novel thionated derivative that relies on one-pot methodologies, thus decreasing the number of purification steps required. This route provides the drug in an overall 62% yield and >99% purity and uses cheap and readily available bulk chemicals, thereby providing an affordable synthesis of the drug for cheaper and wider global accessibility. American Chemical Society 2021-10-11 /pmc/articles/PMC8552467/ /pubmed/34723033 http://dx.doi.org/10.1021/acsomega.1c04550 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Dey, Raghunath
Nayak, Sourav
Das, Parthasarathi
Yadav, Somnath
Short Synthesis of Molnupiravir (EIDD-2801) via a Thionated Uridine Intermediate
title Short Synthesis of Molnupiravir (EIDD-2801) via a Thionated Uridine Intermediate
title_full Short Synthesis of Molnupiravir (EIDD-2801) via a Thionated Uridine Intermediate
title_fullStr Short Synthesis of Molnupiravir (EIDD-2801) via a Thionated Uridine Intermediate
title_full_unstemmed Short Synthesis of Molnupiravir (EIDD-2801) via a Thionated Uridine Intermediate
title_short Short Synthesis of Molnupiravir (EIDD-2801) via a Thionated Uridine Intermediate
title_sort short synthesis of molnupiravir (eidd-2801) via a thionated uridine intermediate
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552467/
https://www.ncbi.nlm.nih.gov/pubmed/34723033
http://dx.doi.org/10.1021/acsomega.1c04550
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