Teriflunomide Treatment of Multiple Sclerosis Selectively Modulates CD8 Memory T Cells

BACKGROUND AND OBJECTIVES: Inhibition of de novo pyrimidine synthesis in proliferating T and B lymphocytes by teriflunomide, a pharmacological inhibitor of dihydroorotate dehydrogenase (DHODH), has been shown to be an effective therapy to treat patients with MS in placebo-controlled phase 3 trials....

Descripción completa

Detalles Bibliográficos
Autores principales: Tilly, Gaëlle, Cadoux, Marion, Garcia, Alexandra, Morille, Jérémy, Wiertlewski, Sandrine, Pecqueur, Claire, Brouard, Sophie, Laplaud, David, Degauque, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552527/
https://www.ncbi.nlm.nih.gov/pubmed/34721394
http://dx.doi.org/10.3389/fimmu.2021.730342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552527/
https://www.ncbi.nlm.nih.gov/pubmed/34721394
http://dx.doi.org/10.3389/fimmu.2021.730342

Ejemplares similares