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Teriflunomide Treatment of Multiple Sclerosis Selectively Modulates CD8 Memory T Cells

BACKGROUND AND OBJECTIVES: Inhibition of de novo pyrimidine synthesis in proliferating T and B lymphocytes by teriflunomide, a pharmacological inhibitor of dihydroorotate dehydrogenase (DHODH), has been shown to be an effective therapy to treat patients with MS in placebo-controlled phase 3 trials....

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Detalles Bibliográficos
Autores principales:	Tilly, Gaëlle, Cadoux, Marion, Garcia, Alexandra, Morille, Jérémy, Wiertlewski, Sandrine, Pecqueur, Claire, Brouard, Sophie, Laplaud, David, Degauque, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552527/ https://www.ncbi.nlm.nih.gov/pubmed/34721394 http://dx.doi.org/10.3389/fimmu.2021.730342

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