Cargando…
Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells
Chronic hepatitis C virus (HCV) infection induces liver inflammation that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Inflammation is the outcome of the action of proinflammatory cytokines and chemokines, including interleukin-1 beta (IL-1β) and tumor necrosis factor alpha....
Autores principales: | Ramachandran, Akshaya, Kumar, Binod, Waris, Gulam, Everly, David |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552718/ https://www.ncbi.nlm.nih.gov/pubmed/34431717 http://dx.doi.org/10.1128/spectrum.00755-21 |
Ejemplares similares
-
STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection
por: Wang, Wenbiao, et al.
Publicado: (2020) -
Deubiquitination of CD36 by UCHL1 promotes foam cell formation
por: Xia, Xiaohong, et al.
Publicado: (2020) -
Structural Insights into the Phosphorylation-Enhanced Deubiquitinating Activity of UCHL3 and Ubiquitin Chain Cleavage Preference Analysis
por: Ren, Yujing, et al.
Publicado: (2022) -
NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs
por: Zhao, Wenhua, et al.
Publicado: (2023) -
HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells
por: Chen, Wei, et al.
Publicado: (2014)