A 28-Day Toxicity Study of Tenofovir Alafenamide Hemifumarate by Subcutaneous Infusion in Rats and Dogs

The toxicity of tenofovir alafenamide (TAF) hemifumarate (HF) was evaluated when administered by continuous subcutaneous (s.c.) infusion via an external infusion pump for 28 days to rats and dogs. The toxicokinetics of TAF and two metabolites, tenofovir (TFV) and tenofovir diphosphate (TFV-DP) were...

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Detalles Bibliográficos
Autores principales: Zane, Doris, Roller, Shane, Shelton, Josephine, Singh, Roshni, Jain, Rachna, Wang, Yan, Yang, Bing, Felx, Melanie, Alessi, Thomas, Feldman, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552772/
https://www.ncbi.nlm.nih.gov/pubmed/34190595
http://dx.doi.org/10.1128/spectrum.00339-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552772/
https://www.ncbi.nlm.nih.gov/pubmed/34190595
http://dx.doi.org/10.1128/spectrum.00339-21

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