Time to revisit the endpoint dilution assay and to replace the TCID(50) as a measure of a virus sample’s infection concentration

The endpoint dilution assay’s output, the 50% infectious dose (ID(50)), is calculated using the Reed-Muench or Spearman-Kärber mathematical approximations, which are biased and often miscalculated. We introduce a replacement for the ID(50) that we call Specific INfection (SIN) along with a free and...

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Detalles Bibliográficos
Autores principales: Cresta, Daniel, Warren, Donald C., Quirouette, Christian, Smith, Amanda P., Lane, Lindey C., Smith, Amber M., Beauchemin, Catherine A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553042/
https://www.ncbi.nlm.nih.gov/pubmed/34662338
http://dx.doi.org/10.1371/journal.pcbi.1009480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553042/
https://www.ncbi.nlm.nih.gov/pubmed/34662338
http://dx.doi.org/10.1371/journal.pcbi.1009480

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