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Time to revisit the endpoint dilution assay and to replace the TCID(50) as a measure of a virus sample’s infection concentration
The endpoint dilution assay’s output, the 50% infectious dose (ID(50)), is calculated using the Reed-Muench or Spearman-Kärber mathematical approximations, which are biased and often miscalculated. We introduce a replacement for the ID(50) that we call Specific INfection (SIN) along with a free and...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553042/ https://www.ncbi.nlm.nih.gov/pubmed/34662338 http://dx.doi.org/10.1371/journal.pcbi.1009480 |